These medications do not fit cleanly into any of the above categories, but all have a defined role in the treatment of rheumatic disease. Agents discussed below include long-term therapies for the control of gout (allopurinol, probenecid), medications to stimulate the flow of saliva in patients with Sjogren’s syndrome (pilocarpine, cevimeline), antihistamines (diphenhydramine, hydroxyzine, loratidine, fexofenadine, cetirizine), antibiotics used for their effect on inflammation (minocycline, trimethoprim/sulfamethoxazole), agents used to treat cutaneous (skin) manifestations of rheumatic diseases (dapsone, thalidomide), and the multi-purpose drug bromocriptine.

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