Trade Name(s):
Available
Dose
Indications
N/A
Side Effects
This medication is usually well-tolerated, but can cause nausea, decreased appetite, and rash. Because probenecid works by increasing uric acid excretion in the urine, fluid intake must be adequate, and individuals with a history of uric acid stones or impaired kidney function are not good candidates to take this medication.
Monitoring
Uric acid levels should be checked every 2-4 weeks while adjusting the dose of probenecid and can be monitored less frequently thereafter.
Important Points to Know
Take this medication with food to decrease upset stomach. Drink enough fluid to produce about 2 quarts of urine daily. The dose of probenecid should not be adjusted during an attack of gout, as it may worsen the symptoms. Like allopurinol, it is used to prevent attacks, not to treat them while they are occurring.