Trade Name(s):
Available
Dose
Indications
Mainly used to bring down elevated calcium levels associated with cancer but is being studied as an alternative treatment for osteoporosis (FDA approval pending)
Side Effects
Nausea, vomiting, bone pain, and headache are minor side effects. During infusions, reactions can uncommonly occur that may include fever, decreased blood pressure, cough, and shortness of breath.
Monitoring
Bone density testing should be performed every 1-2 years to assess the efficacy of therapy. Kidney function testing, calcium, phosphorus, and magnesium levels should be checked prior to starting zoledronic acid and several months following the infusion.
Important Points to Know
Patients with severe kidney disease should not receive this medication as it will not adequately clear from their system. Patients should drink enough fluids for several days after taking this medication to excrete about 2 quarts of urine daily. Please inform your provider if you have a medical condition that requires you to limit your fluid intake. Using zoledronic acid with certain medications classified as diuretics may cause lowered blood levels of calcium. Inform your provider if you are either allergic to aspirin or have aspirin-sensitive asthma, as these patients have an increased risk of infusion reactions.